Trimethyl(1,1,2,2-tetrafluoro-2-phenylsulfonylethyl)silane

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
PhSO2CF2CF2SiMe3
Tetrafluoroethylating Reagent
KUMI4F06
1626431-89-7
 
91353605
27875893
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
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Trimethyl(1,1,2,2-tetrafluoro-2-phenylsulfonylethyl)silane
C11H14F4O2SSi
314.38
≥98.0%
Colorless Liquid to White Slurry or Solid
37-39°C
314.5±42°C
5g,10g,50g,100g,500g and 1kg
Store at room temperature
Trimethyl(1,1,2,2-tetrafluoro-2-phenylsulfonylethyl)silane(PhSO2CF2CF2SiMe3) can be empolyed for nucleophilic tetrafluoroethylation of carbonyl compounds to afford rare alcohols containging the CF2CF2 motif. This newly reported reagent extend the synthetic toolkit for selective introduction of tetrafluoroethyl groups by nucleophilic additions. It also provides an easy route for synthesis of primary,secondary and tertiary amines containing the tetrafluoroethyl group, which  are very important fluorinated compounds in pharmaceutical research.
Nucleophilic tetrafluoroethylation of carbonyl compounds with fluorinated sulfones. [1]
Synthesis of tetrafluoroethyl- and tetrafluoroethylene-containing amines by the reaction of silanes with enamines under acidic conditions. [2]
References:
[1] J.Václavík, Y.Chernykh, B.Jurásek, P.Beier, J.F.Chem., 2015, 169, pp 24-31.
[2] Y.Chernykh, B.Jurásek, P.Beier, J.F.Chem., 2015, 171, pp 162-168.
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