7-(2-(3,3-dimethyl-1λ3-benzo[d][1,2]iodaoxol-1(3H)-yl)-1,1,2,2-tetrafluoroethoxy)-4-methyl-2H-chromen-2-one
Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Togni-CF2CF2X reagent, Alcohol-CF2CF2X reagent
Tetrafluoroethylating Reagents
KUMI4F13
1883744-14-6
 

29301437
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Melting Point
Packaging
Storage
7-(2-(3,3-dimethyl-1λ3-benzo[d][1,2]iodaoxol-1(3H)-yl)-1,1,2,2-tetrafluoroethoxy)-4-methyl-2H-chromen-2-one
C21H17F4IO4
536.26
≥98.0%
Yellow Solid
132°C
5g,10g,100g,500g and 1kg
Store at 2-8°C(recommended)
It is a new hypervalent iodine reagent derived from the 1,2-dihydro-3,3-dimethyl-1,2-benziodoxole scaffold for linking a UV absorber moiety as functional group to the tetrafluoroethyl bridge unit. The high reactivity of this compound towards thiols has been exploited for the selective tagging of several targets with the UV chromophore coumarin, including e.g. glutathione.
Synthesis of quaternary α-perfluoroalkyl lactams via electrophilic perfluoroalkylation. [1]
Hypervalent Iodine Reagents: Thiol Derivatization with a Tetrafluoroethoxy Coumarin Residue for UV Absorbance Recognition. [2]
References:
[1] D.Katayew, J.Václavík, F. Brüning, B. Commare, A. Togni, Chem. Commun., 2016, 52(21), pp 4049-4052.
[2] B. Commare, A. Togni, Helv. Chim., 2017,100(5).
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
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