Thepentafluorosulfanyl (–SF5) group has been described as a "supertrifluoromethyl group" because of its enhanced lipophilicity, electronegativity, and metabolic stability. The sulfur atom in the SF5 group is in a hypervalent hexacoordinated state and the ligands are bonded in an octahedral geometry.
These compounds containing the pentafluorosulfanyl group (–SF5) have been attracting attention as potent building blocks in the fields of pharmaceuticals, agrochemicals and functional materials. Relatively recently, It has emerged as a promising substituent in the design of drugs and crop protective agents, such as Treatment of Alzheimer's disease (Astrazeneca), Antidiabetic agents (Schering Corporation), Treatment of ischemic disease (Sanofi-Aventis), Anti-cancer drugs (Hoffmanne-la Roche), Horticultural insecticide (Nippon Noyaku), Antiparasitic agents (Novartis, Pfizer), Parasiticides (Pfizer), and so on.
Kumidas is pleased to offer a series of pentafluorosulfanyl (–SF5) compounds to accelerate your drug and material development programs.
Pentafluorosulfanyl Compounds Overview
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