4,4,5,5,5-Pentafluoro-1-pentanethiol

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4,4,5,5,5-Pentafluoropentane-1-thiol, Fulvestrant Intermediate
Pentafluoroethylating Reagents, API & Intermediates
KUMI5F08
148757-88-4
MFCD07368915
11138000
7017879
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Boiling Point
Packaging
Storage
4,4,5,5,5-Pentafluoro-1-pentanethiol
C5H7F5S
194.16
≥98.0%(GC)
Colorless to Pale yellow Clear Liquid
112-114°C
5g,10g,50g,100g,500g and 1kg
Store at room temperature
4,4,5,5,5-Pentafluoro-1-pentanethiol is a useful building block and intermediate employed in the preparation and fluorination of fulvestrant 11β isomers which shows antiproliferative activity on MCF-7 cells for breast cancer treatment. It also used as an important chain of anti-breast cancer agent.
Laboratory scale preparation of 4,4,5,5,5-pentafluoropentan-1-thiol: An important chain of anti-breast cancer agents. [1]
Antiestrogenic activities of 3,8-dihydroxy-6,11-dihydrobenzo[a]carbazoles with sulfur-containing side chains. [2]
Effect of Fluorination on the Pharmacological Profile of 11β Isomers of Fulvestrant in Breast Carcinoma Cells. [3]
An alternative synthesis of the breast cancer drug fulvestrant (Faslodex®): catalyst control over C–C bond formation. [4]
References:
[1] X.Li, et al, Tetrahedron Lett., 1994, 35(49), pp 9141-9144.
[2] T.Golob, et al, Arch. Pharm.(Weinheim), 2000, 333(9), pp 305-311.
[3] V.Agouridas, et al, J. Med. Chem., 2009, 52(3), pp 883-887.
[4] D.Carprioglio, et al, Chem. Commun., 2015, 51(80), pp 14866-14868.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H226,H302+H312+H332,H315,H319,H335
P210,P260,P271,P280
2930909899
UN 1993 3/PG III

1. Product Specification
2. Safety Data Sheet
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