(R)-N-Tosyl-S-fluoromethyl-S-phenylsulfoximine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
PhSO(NTs)CH2F
Fluoromethylating Reagents,Fluoromethylenating reagents
KUMI1F10
1422176-84-8
 

22893333
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Melting Point
Packaging
Storage
(R)-N-Tosyl-S-fluoromethyl-S-phenylsulfoximine
C14H14FNO3S2
327.39
≥98.0%
White Solid
89-91°C
5g,10g,50g and 50g
Store at room temperature
A new chiral (mono)fluoromethylenation reagent towards electrophiles such as α,β-unsaturated Weinreb amides. The reaction is general and a variety of structurally diverse α,β-unsaturated Weinreb amides can be monofluoromethylenated to give the corresponding monofluorinated  cyclopropanes in good yield, with good diastereoselectivity, and with excellent enantioselectivity.
Efficient Synthesis and Ring-Opening Reactions of Monofluorinated Epoxides Derived from α-Fluorosulfoximines.[1]
Enantioselective Synthesis of Cyclopropanes That Contain Fluorinated Tertiary Stereogenic Carbon Centers: A Chiral α-Fluoro Carbanion Strategy.[2]
References:
[1] W.Zhang, J. Hu, Adv. Synth. Catal., 2010, 352(16), pp 2799-2804.
[2] X. Shen, W. Zhang, L. Zhang, T. Luo, X. Wan, Y. Gu, J. Hu, Angew. Chem. Int. Ed., 2012, 51(28), pp 6966-6970.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information






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