Fluoromethyl phenyl sulfone(PhSO2CH2F) is a useful nucleophilic monofluoromethylation reagent for the synthesis of fluoromethyl alcohols and amines. In the nucleophilic reaction step, strong bases such as LiHMDS and n-BuLi are used to generate the nucleophilic (phenylsulfonyl)fluoromethyl anion. In the desulfonylation step, sodium/mercury amalgam and magnesium are the commonly used reductive reagents. Besides, the addition reaction between fluoromethyl phenyl sulfone and carbonyls can be used to prepare monofluoroaklenes via acylation–elimination.
A Novel and Efficient Synthesis of Fluoromethyl Phenyl Sulphone and Its Use as a Fluoromethyl Wittig Equivalent.
Stereoselective nucleophilic monofluoromethylation of N-(tert- butanesulfinyl)imines with fluoromethyl phenyl sulfone.
Nucleophilic fluoroalkylation of α,β-enones, arynes, and activated alkynes with fluorinated sulfones: Probing the hard/soft nature of fluorinated carbanions.
Stereoselective monofluoromethylation of N-tert-butylsulfinyl ketimines using pregenerated fluoro(phenylsulfonyl)methyl anion.
Synthesis of fluorinated β-ketosulfones and gem-disulfones by nucleophilic fluoroalkylation of esters and sulfinates with di- and monofluoromethyl sulfones.
 M. Inbasekaran, N.P.Peet, J.R.McCarthy,M.E.LeTourneau, J. Chem. Soc., Chem. Commun., 1985,10,pp 678-679.