Fluoromethyl 2-pyridyl sulfone

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2-((fluoromethyl)sulfonyl)pyridine,(2-Py)SO2CH2F
Fluoromethylating Reagents
KUMI1F07
1365765-53-2
 
119097977
22467670
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Melting Point
Packaging
Storage
Fluoromethyl 2-pyridyl sulfone
C6H6FNO2S
175.18
≥98.0%,(NMR)
Colorless to white solid
83-85°C
5g,10g,50g and 100g
Store at room temperature
Fluoromethyl 2-pyridyl sulfone((2-Py)SO2CH2F) and its derivatives can be used as novel monofluoromethylation reagents. The monofluorinated sulfinate intermediates during the monofluoroolefination of aldehydes and ketones can be halogenated in situ to afford mono- and dihalofluoroalkyl compounds. The coupling reaction between iodofluoromethyl 2-pyridyl sulfone and aryl iodides mediated by copper can be used to prepare monofluoromethyl arenes and heteroarenes.
From olefination to alkylation: In-situ halogenation of julia-kocienski intermediates leading to formal nucleophilic iodo- and bromodifluoromethylation of carbonyl compounds. [1]
Copper-mediated fluoroalkylation of aryl iodides enables facile access to diverse fluorinated compounds: The important role of the (2-Pyridyl)sulfonyl group.[2]
References:
[1] Y. Zhao, B. Gao, J.Hu, J. Am. Chem. Soc., 2012, 134(13), pp 5790-5793.
[2] Y. Zhao, B. Gao, C.Ni, J.Hu, Org. Lett., 2012, 14(23), pp 6080-6083.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319
P264,P280
2933.39.9100
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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