Fluoromethyl 2-pyridyl sulfone((2-Py)SO2CH2F) and its derivatives can be used as novel monofluoromethylation reagents. The monofluorinated sulfinate intermediates during the monofluoroolefination of aldehydes and ketones can be halogenated in situ to afford mono- and dihalofluoroalkyl compounds. The coupling reaction between iodofluoromethyl 2-pyridyl sulfone and aryl iodides mediated by copper can be used to prepare monofluoromethyl arenes and heteroarenes.
From olefination to alkylation: In-situ halogenation of julia-kocienski intermediates leading to formal nucleophilic iodo- and bromodifluoromethylation of carbonyl compounds.
Copper-mediated fluoroalkylation of aryl iodides enables facile access to diverse fluorinated compounds: The important role of the (2-Pyridyl)sulfonyl group.
 Y. Zhao, B. Gao, J.Hu, J. Am. Chem. Soc., 2012, 134(13), pp 5790-5793.
 Y. Zhao, B. Gao, C.Ni, J.Hu, Org. Lett., 2012, 14(23), pp 6080-6083.