1-(Trifluoromethylthio)pyrrolidine-2,5-dione

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-(trifluoromethylsulfanyl)pyrrolidine-2,5-dione
Trifluoromethylthiolating Reagents
KUMI3F208
183267-04-1

15805176
7583473
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
1-(Trifluoromethylthio)pyrrolidine-2,5-dione
C5H4F3NO2S
199.15
≥98%
White to Off-white Solid
96-97°C
5g,10g,25g,50g,100g and 500g
Store at room temperature
1-(Trifluoromethylthio)pyrrolidine-2,5-dione is a useful electrophilic trifuoromethylthiolating reagent for the synthesis of various trifluoromethylthiolated compounds of interest.
Palladium-catalyzed trifluoromethylthiolation of aryl C-H bonds. [1]
Catalytic asymmetric sulfenylation to structurally diverse dithioketals. [2]
Palladium(II)-catalyzed directed trifluoromethylthiolation of unactivated C(sp3)-H bonds. [3]
Regioselective ortho-trifluoromethylthiolation of 2-arylbenzo[d]thiazole via tandem substrate-assisted C-H iodination and trifluoromethylthiolation. [4]
Visible Light-Promoted Decarboxylative Di- A nd Trifluoromethylthiolation of Alkyl Carboxylic Acids. [5]
Pd-catalyzed diastereoselective trifluoromethylthiolation of functionalized acrylamides. [6]
Cooperative Catalysis: A Strategy to Synthesize Trifluoromethyl-thioesters from Aldehydes. [7]
Trifluoromethylthiolation of α-Chloroaldehydes: Access to Quaternary SCF3-Containing Centers. [8]
References:
[1] C.Xu, et al, Org. Lett., 2014, 16(7), pp 2046-2049.
[2] K.Liao, et al, Chem. Commun., 2015, 51(90), pp 16255-16258.
[3] H.Xiong, et al, J. Org. Chem., 2015, 80(18), pp 4204-4212.
[4] P.Luo, et al, Org. Biomol. Chem., 2016, 14(10), pp 2924-2929..
[5] L.Candish, et al, Chem. Eur. J., 2016, 22(14), pp 4753-4756.
[6] Q.Zhao, et al, Org. Lett., 2017, 19(19), pp 5106-5109.
[7] S.Mukherjee, et al, ACS Catal., 2018, 8(7), pp 5842-5846.
[8] F.Gelat, et al, Eur. J. Org. Chem., 2018, 2018(27), pp 3693-3696.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
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Not listed Substance or mixture



NONH for all modes of transport

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