2-(Trifluoromethoxy)benzoic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
O-trifluoromethoxybenzoic acid
Trifluoromethoxylating Building Blocks
KUMI3F192
1979-29-9
MFCD00052325
2777223
2645481
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2-(Trifluoromethoxy)benzoic acid
C8H5F3O3
206.12
≥97%
White to Yellow Solid
75-80°C
5g,10g,25g,50g,100g,200g and 500g
Store at 2-8°C
2-(Trifluoromethoxy)benzoic acid is a useful trifluoromethoxylated building block to prepare various pharmaceutical compounds of interest.
2-,3-,and 4-(Trifluoromethoxy)phenyllithiums: Versatile intermediates offering access to a variety of new organofluorine compounds. [1]
Aminopiperidine sulfonamide Cav2.2 channel inhibitors for the treatment of chronic pain. [2]
Synthesis and evaluation of novel 4-nitropyrrole-based 1,3,4-oxadiazole derivatives as antimicrobial and anti-tubercular agents. [3]
Design, synthesis, biological evaluation of substituted benzofurans as DNA gyraseB inhibitors of Mycobacterium tuberculosis. [4]
Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs. [5]
Aloperine and Its Derivatives as a New Class of HIV-1 Entry Inhibitors. [6]
Synthesis of novel coumarin substituted amide derivatives and their antibacterial activities. [7]
Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents. [8]
Catalytic C−H Trifluoromethoxylation of Arenes and Heteroarenes. [9]
References:
[1] E.Castagnetti, et al, Eur. J. Org. Chem., 2001, 4, pp 691-695.
[2] P.P.Shao, et al, J. Med. Chem., 2012, 55(22), pp 9847-9855.
[3] R.A.Rane, et al, Eur. J. Med. Chem., 2013, 70, pp 49-58.
[4] J.Renuka, et al, Bioorg. Med. Chem., 2014, 22(17), pp 4924-4934.
[5] L.D.Fader, et al, ACS Med. Chem. Lett., 2016. 7(8), pp 797-801.
[6] Z.Dang, et al, ACS Med. Chem. Lett., 2016, 7(3), pp 240-244.
[7] M.Chen, et al, Chem. Pap., 2017, 71(9), pp 1579-1586.
[8] T.Kojima, et al, Bioorg. Med. Chem., 2018, 26(9), pp 2452-2465.
[9] W.Zhang, et al, Angew. Chem. Int. Ed., 2018, 57(31), pp 9645-9649.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H319
P305+P351+P338
2918999090
NONH for all modes of transport

1. Product specification
2. Safety Data Sheet
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