3-(Trifluoromethoxy)benzyl bromide

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-(bromomethyl)-3-(trifluoromethoxy)benzene
Trifluoromethoxylating Building Blocks
KUMI3F181
159689-88-0
MFCD00061271
737176
8052203
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
3-(Trifluoromethoxy)benzyl bromide
C8H6BrF3O
255.03
≥98%(GC)
Colorless to Light Yellow Liquid
178-190°C
5g,10g,25g,50g,100g,200g and 500g
Store at 2-8°C
3-(Trifluoromethoxy)benzyl bromide is a useful building block to prepare the functionalized trifluoromethoxyl substituted aromatic compounds in pharamceuticals and material science.
Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis. [1]
Synthesis and properties of fluorine-containing poly (arylenemethylene) s as new heat resistant denatured phenolic resins. [2]
Pyrido[1,2-a]benzimidazole-based agents active against tuberculosis (TB), multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB. [3]
Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists. [4]
Synthesis and biological evaluation of 2-benzylamino-4(5)-(6-methylpyridin-2-yl)-5(4)-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)thiazoles as transforming growth factor-β type 1 receptor kinase inhibitors. [5]
Antitumor agents 292. Design, synthesis and pharmacological study of S- and O-substituted 7-mercapto- or hydroxy-coumarins and chromones as potent cytotoxic agents. [6]
Design, synthesis and biological evaluation of novel aliphatic amido/sulfonamido-quaternary ammonium salts as antitumor agents. [7]
Design and synthesis of guanylthiourea derivatives as potential inhibitors of Plasmodium falciparum dihydrofolate reductase enzyme. [8]
Synthesis and anti-tubercular activity of 2-nitroimidazooxazines with modification at the C-7 position as PA-824 analogs. [9]
Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1). [10]
Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. [11]
Discovery of the selective sphingomyelin synthase 2 inhibitors with the novel structure of oxazolopyridine. [12]
References:
[1] C.R.Hopkins, et al, Bioorg. Med. Chem. Lett., 2006, 16(21), pp 5659-5667.
[2] T.Nemoto, et al, Polym. J. 2008, 40(7), pp 622-628.
[3] M.Pieroni, et al, ChemMedChem, 2011, 6(2), pp 334-342.
[4] P.M.Cowley, et al, Bioorg. Med. Chem. Lett., 2011, 21(7), pp 2034-2039.
[5] M.Krishnaiah, et al, Eur. J. Med. Chem., 2012, 57, pp 74-84.
[6] Y.Chen, et al, Eur. J. Med. Chem., 2012, 49, pp 74-85.
[7] D.Song, et al, Bioorg. Med. Chem., 2013, 21(3), pp 788-794.
[8] L.Adane, et al, Bioorg. Med. Chem. Lett., 2014, 24(2), pp 613-617.
[9] Y.G.Kang, et al, Bioorg. Med. Chem. Lett., 2015, 25(17), pp 3650-3653.
[10] H.U. Kaniskan, et al, MedChemComm, 2016, 7(9), pp 1793-1796.
[11] A.M.Jarrad, et al, Eur. J. Med. Chem., 2016, 120, pp 353-362.
[12] X.Y.Qi, et al, Bioorg. Med. Chem. Lett., 2017, 27(15), pp 3511-3515.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H314
P280,P305+P351+P338,P310
2909309090
UN 3265 8/PG II

1. Product specification
2. Safety Data Sheet
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