Fluoroiodomethane

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Fluoromethyl Iodide, FIM
Fluoromethylating Reagents
KUMI1F303
373-53-5
MFCD12404952
13981373
4983662
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
Fluoroiodomethane
CH2FI
159.93
≥99.8% (ca. 2mol/L in Acetonitrile)
Colorless to Very Light Reddish Liquid
53-54°C
25g,50g,100g,500g and 1kg
Avoid Light
Fluoroiodomethane (also known as Fluoromethyl Iodide, FIM) is a reagent for the introduction of the fluoromethyl (FCH2) group. It is typically used as non-ozone depleting alternative to Bromofluoromethane (BFM) for fluoromethylation of steroids, including fluticasone propionate and fluticasone furoate.
Synthesis and Structure-Activity Relationships in a Series of Antiinflammatory Corticosteroid Analogs, Halomethyl Androstane-17.beta.-carbothioates and -17.beta.-carboselenoates. [1]
Synthesis of Monofluoromethylthioesters from Aldehydes. [2]
References:
[1] G.H.Phillipps, et al, J. Med. Chem., 1994, 37(22), pp 3717-3729.
[2] G.Landelle, et al, 2011, Encyclopedia of Reagents for Organic Synthesis. e-EROS Encyclopedia of Reagents for Organic Synthesis.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H225,H311,H315,H319,H332,H341,H370,H373
P201,P202,P210,P233,P240,310,P260,P264,P270,P271,P280,P305+P351+P338
29051100
UN3265 8/PG II

1. Product Specification
2. Safety Data Sheet
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